Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2292437..2293041 Replicon chromosome
Accession NZ_CP117609
Organism Escherichia albertii strain BIA_26

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag PS038_RS11005 Protein ID WP_000638401.1
Coordinates 2292655..2293041 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS038_RS11000 Protein ID WP_001195490.1
Coordinates 2292437..2292658 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS038_RS10985 (2288906) 2288906..2289031 - 126 Protein_2149 trans-aconitate 2-methyltransferase -
PS038_RS10990 (2289352) 2289352..2290704 - 1353 WP_000347609.1 SIR2 family protein -
PS038_RS10995 (2290919) 2290919..2292097 - 1179 Protein_2151 helix-turn-helix domain-containing protein -
PS038_RS11000 (2292437) 2292437..2292658 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS038_RS11005 (2292655) 2292655..2293041 + 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS038_RS11010 (2293121) 2293121..2294008 - 888 Protein_2154 autotransporter outer membrane beta-barrel domain-containing protein -
PS038_RS11015 (2294100) 2294100..2295719 + 1620 WP_273818010.1 ISL3-like element ISEc38 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2287587..2295719 8132
- inside IScluster/Tn - - 2287587..2295719 8132


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T271683 WP_000638401.1 NZ_CP117609:2292655-2293041 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271683 WP_001195490.1 NZ_CP117609:2292437-2292658 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References