Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 894863..895514 Replicon chromosome
Accession NZ_CP117609
Organism Escherichia albertii strain BIA_26

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS038_RS04315 Protein ID WP_000244763.1
Coordinates 895110..895514 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS038_RS04310 Protein ID WP_000354046.1
Coordinates 894863..895129 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS038_RS04285 (890575) 890575..892008 - 1434 WP_059218198.1 6-phospho-beta-glucosidase BglA -
PS038_RS04290 (892053) 892053..892364 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS038_RS04295 (892532) 892532..893191 + 660 WP_000250281.1 hemolysin III family protein -
PS038_RS04300 (893631) 893631..894611 - 981 WP_000886056.1 tRNA-modifying protein YgfZ -
PS038_RS04305 (894643) 894643..894873 + 231 WP_000181267.1 hypothetical protein -
PS038_RS04310 (894863) 894863..895129 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS038_RS04315 (895110) 895110..895514 + 405 WP_000244763.1 protein YgfX Toxin
PS038_RS04320 (895548) 895548..896069 - 522 WP_054410387.1 flavodoxin FldB -
PS038_RS04325 (896181) 896181..897077 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS038_RS04330 (897102) 897102..897812 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS038_RS04335 (897818) 897818..899551 + 1734 WP_059218077.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271675 WP_000244763.1 NZ_CP117609:895110-895514 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271675 WP_000354046.1 NZ_CP117609:894863-895129 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References