Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 73321..73946 Replicon plasmid pEA29_1
Accession NZ_CP117607
Organism Escherichia albertii strain BIA_29

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PS031_RS23060 Protein ID WP_000911317.1
Coordinates 73548..73946 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag PS031_RS23055 Protein ID WP_000450532.1
Coordinates 73321..73548 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS031_RS23055 (73321) 73321..73548 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
PS031_RS23060 (73548) 73548..73946 + 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
PS031_RS23065 (73955) 73955..76108 - 2154 WP_262930967.1 type IV conjugative transfer system coupling protein TraD -
PS031_RS23070 (76360) 76360..77091 - 732 WP_273773874.1 conjugal transfer complement resistance protein TraT -
PS031_RS23075 (77123) 77123..77620 - 498 WP_000605859.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - vat / papD / papC / faeI / faeH / faeF / faeE / faeD / faeC 1..116006 116006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T271668 WP_000911317.1 NZ_CP117607:73548-73946 [Escherichia albertii]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT271668 WP_000450532.1 NZ_CP117607:73321-73548 [Escherichia albertii]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References