Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3858042..3858658 Replicon chromosome
Accession NZ_CP117606
Organism Escherichia albertii strain BIA_29

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PS031_RS18860 Protein ID WP_001129491.1
Coordinates 3858284..3858658 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1EQU6
Locus tag PS031_RS18855 Protein ID WP_001275524.1
Coordinates 3858042..3858284 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS031_RS18815 (3853334) 3853334..3853771 + 438 WP_000560977.1 D-aminoacyl-tRNA deacylase -
PS031_RS18820 (3853816) 3853816..3854757 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PS031_RS18825 (3854821) 3854821..3855729 - 909 WP_059239594.1 alpha/beta hydrolase -
PS031_RS18830 (3855958) 3855958..3856269 + 312 WP_000897302.1 hypothetical protein -
PS031_RS18835 (3856270) 3856270..3856560 + 291 WP_000356397.1 NadS family protein -
PS031_RS18840 (3856645) 3856645..3856857 + 213 WP_000197774.1 hypothetical protein -
PS031_RS18845 (3856919) 3856919..3857197 + 279 WP_032278934.1 hypothetical protein -
PS031_RS18850 (3857596) 3857596..3857814 + 219 WP_001314326.1 CopG family transcriptional regulator -
PS031_RS18855 (3858042) 3858042..3858284 + 243 WP_001275524.1 CopG family transcriptional regulator Antitoxin
PS031_RS18860 (3858284) 3858284..3858658 + 375 WP_001129491.1 PIN domain-containing protein Toxin
PS031_RS18865 (3858695) 3858695..3859624 - 930 WP_000027704.1 formate dehydrogenase accessory protein FdhE -
PS031_RS18870 (3859621) 3859621..3860256 - 636 WP_000829019.1 formate dehydrogenase cytochrome b556 subunit -
PS031_RS18875 (3860253) 3860253..3861155 - 903 WP_000331386.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-48)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13956.21 Da        Isoelectric Point: 9.4803

>T271661 WP_001129491.1 NZ_CP117606:3858284-3858658 [Escherichia albertii]
MAKRTALFDTNILIDLFSGRIEAKQALEAWPLQNAISLVTWMEVLVGAKKYNQEHRTRIAMSAFNVIGISQDIAERSVAL
RQEYRMKLPDAIILATAQIYGFELVTRNTRDFAGIAGVITPYQP

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9256.53 Da        Isoelectric Point: 4.3774

>AT271661 WP_001275524.1 NZ_CP117606:3858042-3858284 [Escherichia albertii]
MSAMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVDQYLENQSKTTISSALGIWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B1EQU6

References