Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 260876..261494 Replicon chromosome
Accession NZ_CP117606
Organism Escherichia albertii strain BIA_29

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS031_RS01255 Protein ID WP_001280991.1
Coordinates 260876..261094 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS031_RS01260 Protein ID WP_000344798.1
Coordinates 261120..261494 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS031_RS01220 (256165) 256165..256737 + 573 WP_059216668.1 YbaY family lipoprotein -
PS031_RS01225 (256767) 256767..257078 - 312 WP_000409915.1 MGMT family protein -
PS031_RS01235 (257459) 257459..257812 + 354 WP_000878151.1 DUF1428 family protein -
PS031_RS01240 (257850) 257850..259400 - 1551 WP_001260378.1 EAL domain-containing protein -
PS031_RS01245 (259564) 259564..260034 - 471 WP_000136188.1 YlaC family protein -
PS031_RS01250 (260142) 260142..260699 - 558 WP_204628716.1 maltose O-acetyltransferase -
PS031_RS01255 (260876) 260876..261094 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS031_RS01260 (261120) 261120..261494 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS031_RS01265 (262049) 262049..265198 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS031_RS01270 (265221) 265221..266414 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271645 WP_001280991.1 NZ_CP117606:c261094-260876 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271645 WP_000344798.1 NZ_CP117606:c261494-261120 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References