Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 22586..23111 Replicon plasmid pEA32_3
Accession NZ_CP117603
Organism Escherichia albertii strain BIA_32

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag PS047_RS25240 Protein ID WP_001159871.1
Coordinates 22806..23111 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q3ZU16
Locus tag PS047_RS25235 Protein ID WP_000813639.1
Coordinates 22586..22804 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS047_RS25220 (19902) 19902..20484 + 583 Protein_16 ISL3 family transposase -
PS047_RS25225 (20583) 20583..20783 + 201 Protein_17 transposase -
PS047_RS25235 (22586) 22586..22804 + 219 WP_000813639.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
PS047_RS25240 (22806) 22806..23111 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
PS047_RS25245 (23112) 23112..23918 + 807 WP_273823988.1 site-specific integrase -
PS047_RS25250 (24098) 24098..24742 + 645 WP_001144035.1 ParA family protein -
PS047_RS25255 (24829) 24829..25152 + 324 WP_273823990.1 molecular chaperone GroEL -
PS047_RS25260 (25577) 25577..26557 + 981 WP_273823992.1 plasmid segregation protein ParM -
PS047_RS25265 (26550) 26550..26966 + 417 WP_273823994.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - vat 1..81187 81187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T271643 WP_001159871.1 NZ_CP117603:22806-23111 [Escherichia albertii]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.30 Da        Isoelectric Point: 4.5203

>AT271643 WP_000813639.1 NZ_CP117603:22586-22804 [Escherichia albertii]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DIR5

References