Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4282235..4282853 Replicon chromosome
Accession NZ_CP117600
Organism Escherichia albertii strain BIA_32

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS047_RS21240 Protein ID WP_001280991.1
Coordinates 4282235..4282453 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS047_RS21245 Protein ID WP_000344798.1
Coordinates 4282479..4282853 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS047_RS21205 (4277524) 4277524..4278096 + 573 WP_000779847.1 YbaY family lipoprotein -
PS047_RS21210 (4278126) 4278126..4278437 - 312 WP_000409915.1 MGMT family protein -
PS047_RS21220 (4278818) 4278818..4279171 + 354 WP_273823575.1 DUF1428 family protein -
PS047_RS21225 (4279209) 4279209..4280759 - 1551 WP_001260378.1 EAL domain-containing protein -
PS047_RS21230 (4280923) 4280923..4281393 - 471 WP_000136188.1 YlaC family protein -
PS047_RS21235 (4281501) 4281501..4282058 - 558 WP_059221620.1 maltose O-acetyltransferase -
PS047_RS21240 (4282235) 4282235..4282453 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS047_RS21245 (4282479) 4282479..4282853 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS047_RS21250 (4283408) 4283408..4286557 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS047_RS21255 (4286580) 4286580..4287773 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271639 WP_001280991.1 NZ_CP117600:c4282453-4282235 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271639 WP_000344798.1 NZ_CP117600:c4282853-4282479 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References