Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2772646..2773446 Replicon chromosome
Accession NZ_CP117600
Organism Escherichia albertii strain BIA_32

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag PS047_RS14045 Protein ID WP_059220924.1
Coordinates 2772646..2773173 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS047_RS14050 Protein ID WP_001277106.1
Coordinates 2773180..2773446 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS047_RS14020 (2767721) 2767721..2768488 - 768 WP_059278385.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PS047_RS14025 (2768485) 2768485..2769762 - 1278 WP_273823441.1 branched chain amino acid ABC transporter permease LivM -
PS047_RS14030 (2769759) 2769759..2770685 - 927 WP_000003001.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS047_RS14035 (2770733) 2770733..2771842 - 1110 WP_059220920.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS047_RS14040 (2772266) 2772266..2772649 + 384 WP_059220922.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS047_RS14045 (2772646) 2772646..2773173 - 528 WP_059220924.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS047_RS14050 (2773180) 2773180..2773446 - 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS047_RS14055 (2773596) 2773596..2774699 - 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS047_RS14060 (2774972) 2774972..2775826 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
PS047_RS14065 (2776071) 2776071..2777129 - 1059 WP_001042000.1 permease-like cell division protein FtsX -
PS047_RS14070 (2777122) 2777122..2777790 - 669 WP_000617720.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19490.38 Da        Isoelectric Point: 6.6303

>T271634 WP_059220924.1 NZ_CP117600:c2773173-2772646 [Escherichia albertii]
MDDLTIEILTDDADYDLQRLDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVCSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT271634 WP_001277106.1 NZ_CP117600:c2773446-2773180 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References