Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2184689..2185340 Replicon chromosome
Accession NZ_CP117600
Organism Escherichia albertii strain BIA_32

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS047_RS11135 Protein ID WP_000244763.1
Coordinates 2184689..2185093 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS047_RS11140 Protein ID WP_000354046.1
Coordinates 2185074..2185340 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS047_RS11115 (2180647) 2180647..2182380 - 1734 WP_059221131.1 single-stranded-DNA-specific exonuclease RecJ -
PS047_RS11120 (2182386) 2182386..2183096 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS047_RS11125 (2183121) 2183121..2184017 - 897 WP_059221133.1 site-specific tyrosine recombinase XerD -
PS047_RS11130 (2184129) 2184129..2184650 + 522 WP_059221135.1 flavodoxin FldB -
PS047_RS11135 (2184689) 2184689..2185093 - 405 WP_000244763.1 protein YgfX Toxin
PS047_RS11140 (2185074) 2185074..2185340 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS047_RS11145 (2185330) 2185330..2185560 - 231 WP_000181267.1 hypothetical protein -
PS047_RS11150 (2185592) 2185592..2186572 + 981 WP_273823858.1 tRNA-modifying protein YgfZ -
PS047_RS11155 (2186774) 2186774..2187433 - 660 WP_000250281.1 hemolysin III family protein -
PS047_RS11160 (2187601) 2187601..2187912 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS047_RS11165 (2187957) 2187957..2189390 + 1434 WP_059221179.1 6-phospho-beta-glucosidase BglA -
PS047_RS11170 (2189437) 2189437..2190330 - 894 WP_059221140.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271633 WP_000244763.1 NZ_CP117600:c2185093-2184689 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271633 WP_000354046.1 NZ_CP117600:c2185340-2185074 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References