Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 637464..638068 Replicon chromosome
Accession NZ_CP117600
Organism Escherichia albertii strain BIA_32

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PS047_RS03205 Protein ID WP_273823695.1
Coordinates 637464..637850 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS047_RS03210 Protein ID WP_001195490.1
Coordinates 637847..638068 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS047_RS03200 (635958) 635958..637379 + 1422 WP_273823694.1 autotransporter outer membrane beta-barrel domain-containing protein -
PS047_RS03205 (637464) 637464..637850 - 387 WP_273823695.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS047_RS03210 (637847) 637847..638068 - 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS047_RS03215 (638432) 638432..638512 + 81 Protein_636 trans-aconitate 2-methyltransferase -
PS047_RS03220 (638516) 638516..639430 - 915 WP_024164792.1 bestrophin family protein -
PS047_RS03225 (639635) 639635..641086 - 1452 WP_059220135.1 tagaturonate reductase -
PS047_RS03230 (641333) 641333..641996 - 664 Protein_639 GGDEF domain-containing protein -
PS047_RS03235 (642132) 642132..642494 - 363 WP_001257078.1 DUF4186 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14487.52 Da        Isoelectric Point: 8.0833

>T271625 WP_273823695.1 NZ_CP117600:c637850-637464 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLADPGRAQALIYRVQNRVHYEGVTDLFELAAIYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271625 WP_001195490.1 NZ_CP117600:c638068-637847 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References