Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 56683..57208 Replicon plasmid pEA35_1
Accession NZ_CP117596
Organism Escherichia albertii strain BIA_35

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag PS050_RS23110 Protein ID WP_001159871.1
Coordinates 56903..57208 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag PS050_RS23105 Protein ID WP_000813630.1
Coordinates 56683..56901 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS050_RS23080 (51957) 51957..52226 - 270 WP_000343793.1 hypothetical protein -
PS050_RS23085 (52545) 52545..54116 + 1572 WP_256876213.1 ATP-binding protein -
PS050_RS23090 (54324) 54324..55304 - 981 WP_256876212.1 hypothetical protein -
PS050_RS23095 (55444) 55444..55860 - 417 WP_256876211.1 type II toxin-antitoxin system VapC family toxin -
PS050_RS23100 (55857) 55857..56087 - 231 WP_256876210.1 type II toxin-antitoxin system VapB family antitoxin -
PS050_RS23105 (56683) 56683..56901 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
PS050_RS23110 (56903) 56903..57208 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
PS050_RS23115 (57209) 57209..58015 + 807 WP_000016970.1 site-specific integrase -
PS050_RS23120 (58737) 58737..59492 + 756 Protein_68 replication initiation protein RepE -
PS050_RS23125 (60080) 60080..61246 + 1167 WP_273819238.1 plasmid-partitioning protein SopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - espL2 / vat 1..88900 88900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T271618 WP_001159871.1 NZ_CP117596:56903-57208 [Escherichia albertii]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT271618 WP_000813630.1 NZ_CP117596:56683-56901 [Escherichia albertii]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References