Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 55444..56087 Replicon plasmid pEA35_1
Accession NZ_CP117596
Organism Escherichia albertii strain BIA_35

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag PS050_RS23095 Protein ID WP_256876211.1
Coordinates 55444..55860 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag PS050_RS23100 Protein ID WP_256876210.1
Coordinates 55857..56087 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS050_RS23070 (50495) 50495..50836 - 342 Protein_58 protein RepA -
PS050_RS23075 (51373) 51373..51969 - 597 WP_256876215.1 hypothetical protein -
PS050_RS23080 (51957) 51957..52226 - 270 WP_000343793.1 hypothetical protein -
PS050_RS23085 (52545) 52545..54116 + 1572 WP_256876213.1 ATP-binding protein -
PS050_RS23090 (54324) 54324..55304 - 981 WP_256876212.1 hypothetical protein -
PS050_RS23095 (55444) 55444..55860 - 417 WP_256876211.1 type II toxin-antitoxin system VapC family toxin Toxin
PS050_RS23100 (55857) 55857..56087 - 231 WP_256876210.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PS050_RS23105 (56683) 56683..56901 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA -
PS050_RS23110 (56903) 56903..57208 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
PS050_RS23115 (57209) 57209..58015 + 807 WP_000016970.1 site-specific integrase -
PS050_RS23120 (58737) 58737..59492 + 756 Protein_68 replication initiation protein RepE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - espL2 / vat 1..88900 88900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.41 Da        Isoelectric Point: 6.7125

>T271617 WP_256876211.1 NZ_CP117596:c55860-55444 [Escherichia albertii]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAISGHAIAAGAILVTNNTREFERVPGLILEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8678.80 Da        Isoelectric Point: 4.6017

>AT271617 WP_256876210.1 NZ_CP117596:c56087-55857 [Escherichia albertii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGGSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References