Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3434219..3434837 Replicon chromosome
Accession NZ_CP117595
Organism Escherichia albertii strain BIA_35

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS050_RS16625 Protein ID WP_001280991.1
Coordinates 3434619..3434837 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS050_RS16620 Protein ID WP_000344798.1
Coordinates 3434219..3434593 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS050_RS16610 (3429299) 3429299..3430492 + 1194 WP_273818734.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS050_RS16615 (3430515) 3430515..3433664 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS050_RS16620 (3434219) 3434219..3434593 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS050_RS16625 (3434619) 3434619..3434837 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS050_RS16630 (3435014) 3435014..3435571 + 558 WP_000093562.1 maltose O-acetyltransferase -
PS050_RS16635 (3435679) 3435679..3436149 + 471 WP_000136189.1 YlaC family protein -
PS050_RS16640 (3436313) 3436313..3437863 + 1551 WP_273818735.1 EAL domain-containing protein -
PS050_RS16645 (3437901) 3437901..3438254 - 354 WP_000878151.1 DUF1428 family protein -
PS050_RS16655 (3438635) 3438635..3438946 + 312 WP_000409915.1 MGMT family protein -
PS050_RS16660 (3438976) 3438976..3439548 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271604 WP_001280991.1 NZ_CP117595:3434619-3434837 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271604 WP_000344798.1 NZ_CP117595:3434219-3434593 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References