Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 927461..928112 Replicon chromosome
Accession NZ_CP117595
Organism Escherichia albertii strain BIA_35

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS050_RS04560 Protein ID WP_000244763.1
Coordinates 927708..928112 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS050_RS04555 Protein ID WP_000354046.1
Coordinates 927461..927727 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS050_RS04525 (922470) 922470..923363 + 894 WP_025238419.1 transporter -
PS050_RS04530 (923411) 923411..924844 - 1434 WP_059256084.1 6-phospho-beta-glucosidase BglA -
PS050_RS04535 (924889) 924889..925200 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS050_RS04540 (925368) 925368..926027 + 660 WP_000250281.1 hemolysin III family protein -
PS050_RS04545 (926229) 926229..927209 - 981 WP_000886056.1 tRNA-modifying protein YgfZ -
PS050_RS04550 (927241) 927241..927471 + 231 WP_000181267.1 hypothetical protein -
PS050_RS04555 (927461) 927461..927727 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS050_RS04560 (927708) 927708..928112 + 405 WP_000244763.1 protein YgfX Toxin
PS050_RS04565 (928146) 928146..928667 - 522 WP_054410387.1 flavodoxin FldB -
PS050_RS04570 (928779) 928779..929675 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS050_RS04575 (929700) 929700..930410 + 711 WP_059214529.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS050_RS04580 (930416) 930416..932149 + 1734 WP_059216762.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271597 WP_000244763.1 NZ_CP117595:927708-928112 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271597 WP_000354046.1 NZ_CP117595:927461-927727 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References