Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 289547..290347 Replicon chromosome
Accession NZ_CP117595
Organism Escherichia albertii strain BIA_35

Toxin (Protein)


Gene name ataT Uniprot ID B1EHN9
Locus tag PS050_RS01355 Protein ID WP_000342453.1
Coordinates 289820..290347 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS050_RS01350 Protein ID WP_001277106.1
Coordinates 289547..289813 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS050_RS01325 (285268) 285268..286122 - 855 WP_000370583.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
PS050_RS01330 (286115) 286115..286861 - 747 WP_000151888.1 PTS sugar transporter subunit IIC -
PS050_RS01335 (286878) 286878..287363 - 486 WP_059256852.1 PTS sugar transporter subunit IIB -
PS050_RS01340 (287370) 287370..287771 - 402 WP_001071334.1 PTS sugar transporter subunit IIA -
PS050_RS01345 (288294) 288294..289397 + 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS050_RS01350 (289547) 289547..289813 + 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS050_RS01355 (289820) 289820..290347 + 528 WP_000342453.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS050_RS01360 (290344) 290344..290727 - 384 WP_000778774.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS050_RS01365 (291151) 291151..292260 + 1110 WP_000827693.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS050_RS01370 (292308) 292308..293234 + 927 WP_160523110.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS050_RS01375 (293231) 293231..294508 + 1278 WP_059225128.1 branched chain amino acid ABC transporter permease LivM -
PS050_RS01380 (294505) 294505..295272 + 768 WP_044709901.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19676.58 Da        Isoelectric Point: 6.9585

>T271594 WP_000342453.1 NZ_CP117595:289820-290347 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT271594 WP_001277106.1 NZ_CP117595:289547-289813 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References