Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 69618..70143 Replicon plasmid pEA36_2
Accession NZ_CP117592
Organism Escherichia albertii strain BIA_36

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag PS051_RS24650 Protein ID WP_001159871.1
Coordinates 69618..69923 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q3ZU16
Locus tag PS051_RS24655 Protein ID WP_000813639.1
Coordinates 69925..70143 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS051_RS24625 (65795) 65795..66211 - 417 WP_001278818.1 plasmid partitioning/stability family protein -
PS051_RS24630 (66204) 66204..67184 - 981 WP_000688509.1 plasmid segregation protein ParM -
PS051_RS24635 (67591) 67591..67899 - 309 WP_000030204.1 molecular chaperone GroEL -
PS051_RS24640 (67986) 67986..68630 - 645 WP_001144036.1 ParA family protein -
PS051_RS24645 (68809) 68809..69617 - 809 Protein_74 site-specific integrase -
PS051_RS24650 (69618) 69618..69923 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
PS051_RS24655 (69925) 69925..70143 - 219 WP_000813639.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
PS051_RS24660 (70739) 70739..70989 + 251 Protein_77 hypothetical protein -
PS051_RS24665 (70986) 70986..71576 + 591 WP_233929287.1 hypothetical protein -
PS051_RS24670 (72104) 72104..72550 - 447 WP_096959008.1 YhbP family protein -
PS051_RS24675 (72682) 72682..73625 - 944 Protein_80 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..89679 89679


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T271588 WP_001159871.1 NZ_CP117592:c69923-69618 [Escherichia albertii]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.30 Da        Isoelectric Point: 4.5203

>AT271588 WP_000813639.1 NZ_CP117592:c70143-69925 [Escherichia albertii]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DIR5

References