Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 72272..72873 Replicon plasmid pEA36_1
Accession NZ_CP117591
Organism Escherichia albertii strain BIA_36

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag PS051_RS24095 Protein ID WP_001216034.1
Coordinates 72272..72652 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag PS051_RS24100 Protein ID WP_001190712.1
Coordinates 72652..72873 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS051_RS24065 (PS051_24065) 67403..67633 - 231 Protein_69 ash family protein -
PS051_RS24070 (PS051_24070) 67717..69201 - 1485 WP_000124159.1 hypothetical protein -
PS051_RS24075 (PS051_24075) 69201..70394 - 1194 WP_119047760.1 terminase -
PS051_RS24080 (PS051_24080) 70476..70928 - 453 WP_119047761.1 Late promoter-activating protein -
PS051_RS24085 (PS051_24085) 71017..72060 - 1044 WP_273782055.1 DUF968 domain-containing protein -
PS051_RS24090 (PS051_24090) 72088..72267 - 180 WP_001513661.1 hypothetical protein -
PS051_RS24095 (PS051_24095) 72272..72652 - 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS051_RS24100 (PS051_24100) 72652..72873 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS051_RS24105 (PS051_24105) 73056..74612 + 1557 WP_273782056.1 type I restriction-modification system subunit M -
PS051_RS24110 (PS051_24110) 74609..75928 + 1320 WP_273782057.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..103275 103275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T271582 WP_001216034.1 NZ_CP117591:c72652-72272 [Escherichia albertii]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT271582 WP_001190712.1 NZ_CP117591:c72873-72652 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References