Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3520489..3521107 Replicon chromosome
Accession NZ_CP117590
Organism Escherichia albertii strain BIA_36

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS051_RS17610 Protein ID WP_001280991.1
Coordinates 3520889..3521107 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS051_RS17605 Protein ID WP_000344798.1
Coordinates 3520489..3520863 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS051_RS17595 (3515569) 3515569..3516762 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS051_RS17600 (3516785) 3516785..3519934 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS051_RS17605 (3520489) 3520489..3520863 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS051_RS17610 (3520889) 3520889..3521107 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS051_RS17615 (3521284) 3521284..3521841 + 558 WP_059221620.1 maltose O-acetyltransferase -
PS051_RS17620 (3521949) 3521949..3522419 + 471 WP_000136188.1 YlaC family protein -
PS051_RS17625 (3522583) 3522583..3524133 + 1551 WP_273781230.1 EAL domain-containing protein -
PS051_RS17630 (3524171) 3524171..3524524 - 354 WP_000878151.1 DUF1428 family protein -
PS051_RS17640 (3524905) 3524905..3525216 + 312 WP_000409915.1 MGMT family protein -
PS051_RS17645 (3525246) 3525246..3525818 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271577 WP_001280991.1 NZ_CP117590:3520889-3521107 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271577 WP_000344798.1 NZ_CP117590:3520489-3520863 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References