Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 31555..32156 Replicon plasmid pEA40_1
Accession NZ_CP117587
Organism Escherichia albertii strain BIA_40

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag PS042_RS23960 Protein ID WP_001216045.1
Coordinates 31776..32156 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag PS042_RS23955 Protein ID WP_001190712.1
Coordinates 31555..31776 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS042_RS23945 (PS042_23945) 28590..29819 - 1230 WP_256908116.1 restriction endonuclease subunit S -
PS042_RS23950 (PS042_23950) 29816..31372 - 1557 WP_137647606.1 type I restriction-modification system subunit M -
PS042_RS23955 (PS042_23955) 31555..31776 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS042_RS23960 (PS042_23960) 31776..32156 + 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS042_RS23965 (PS042_23965) 32161..32340 + 180 WP_000113018.1 hypothetical protein -
PS042_RS23970 (PS042_23970) 32368..33411 + 1044 WP_256908115.1 DUF968 domain-containing protein -
PS042_RS23975 (PS042_23975) 33500..33967 + 468 WP_089589729.1 Late promoter-activating protein -
PS042_RS23980 (PS042_23980) 34010..35221 + 1212 WP_273777117.1 transposase -
PS042_RS23985 (PS042_23985) 35287..36480 + 1194 WP_256908157.1 terminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..95160 95160
- flank IS/Tn - - 34070..35221 1151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T271559 WP_001216045.1 NZ_CP117587:31776-32156 [Escherichia albertii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT271559 WP_001190712.1 NZ_CP117587:31555-31776 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References