Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3597378..3597996 Replicon chromosome
Accession NZ_CP117586
Organism Escherichia albertii strain BIA_40

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS042_RS17965 Protein ID WP_001280991.1
Coordinates 3597778..3597996 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS042_RS17960 Protein ID WP_000344798.1
Coordinates 3597378..3597752 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS042_RS17950 (3592458) 3592458..3593651 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS042_RS17955 (3593674) 3593674..3596823 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS042_RS17960 (3597378) 3597378..3597752 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS042_RS17965 (3597778) 3597778..3597996 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS042_RS17970 (3598173) 3598173..3598730 + 558 WP_025237467.1 maltose O-acetyltransferase -
PS042_RS17975 (3598837) 3598837..3599307 + 471 WP_000136188.1 YlaC family protein -
PS042_RS17980 (3599471) 3599471..3601021 + 1551 WP_059234326.1 EAL domain-containing protein -
PS042_RS17985 (3601059) 3601059..3601412 - 354 WP_000878151.1 DUF1428 family protein -
PS042_RS17995 (3601793) 3601793..3602104 + 312 WP_000409915.1 MGMT family protein -
PS042_RS18000 (3602134) 3602134..3602706 - 573 WP_256875765.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271552 WP_001280991.1 NZ_CP117586:3597778-3597996 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271552 WP_000344798.1 NZ_CP117586:3597378-3597752 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References