Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 884329..884980 Replicon chromosome
Accession NZ_CP117586
Organism Escherichia albertii strain BIA_40

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS042_RS04295 Protein ID WP_000244763.1
Coordinates 884576..884980 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS042_RS04290 Protein ID WP_000354046.1
Coordinates 884329..884595 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS042_RS04265 (880040) 880040..881473 - 1434 WP_059235410.1 6-phospho-beta-glucosidase BglA -
PS042_RS04270 (881518) 881518..881829 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS042_RS04275 (881997) 881997..882656 + 660 WP_000250281.1 hemolysin III family protein -
PS042_RS04280 (883097) 883097..884077 - 981 WP_059235393.1 tRNA-modifying protein YgfZ -
PS042_RS04285 (884109) 884109..884339 + 231 WP_000181267.1 hypothetical protein -
PS042_RS04290 (884329) 884329..884595 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS042_RS04295 (884576) 884576..884980 + 405 WP_000244763.1 protein YgfX Toxin
PS042_RS04300 (885019) 885019..885540 - 522 WP_059235395.1 flavodoxin FldB -
PS042_RS04305 (885652) 885652..886548 + 897 WP_059228147.1 site-specific tyrosine recombinase XerD -
PS042_RS04310 (886573) 886573..887283 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS042_RS04315 (887289) 887289..889022 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271542 WP_000244763.1 NZ_CP117586:884576-884980 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271542 WP_000354046.1 NZ_CP117586:884329-884595 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References