Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 297720..298520 Replicon chromosome
Accession NZ_CP117586
Organism Escherichia albertii strain BIA_40

Toxin (Protein)


Gene name ataT Uniprot ID A0A8H9C5V7
Locus tag PS042_RS01375 Protein ID WP_000342455.1
Coordinates 297993..298520 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS042_RS01370 Protein ID WP_001277106.1
Coordinates 297720..297986 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS042_RS01350 (293316) 293316..294374 + 1059 WP_001042000.1 permease-like cell division protein FtsX -
PS042_RS01355 (294619) 294619..295473 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
PS042_RS01360 (295670) 295670..296179 + 510 WP_059235675.1 hypothetical protein -
PS042_RS01365 (296467) 296467..297570 + 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS042_RS01370 (297720) 297720..297986 + 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS042_RS01375 (297993) 297993..298520 + 528 WP_000342455.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS042_RS01380 (298517) 298517..298900 - 384 WP_059235673.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS042_RS01385 (299324) 299324..300433 + 1110 WP_256875830.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS042_RS01390 (300481) 300481..301407 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS042_RS01395 (301404) 301404..302681 + 1278 WP_044709902.1 branched chain amino acid ABC transporter permease LivM -
PS042_RS01400 (302678) 302678..303445 + 768 WP_044709901.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19607.47 Da        Isoelectric Point: 6.6343

>T271539 WP_000342455.1 NZ_CP117586:297993-298520 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT271539 WP_001277106.1 NZ_CP117586:297720-297986 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References