Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2599284..2600084 Replicon chromosome
Accession NZ_CP117583
Organism Escherichia albertii strain BIA_41

Toxin (Protein)


Gene name ataT Uniprot ID B1EHN9
Locus tag PS045_RS12685 Protein ID WP_000342453.1
Coordinates 2599284..2599811 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS045_RS12690 Protein ID WP_001277106.1
Coordinates 2599818..2600084 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS045_RS12660 (2594359) 2594359..2595126 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PS045_RS12665 (2595123) 2595123..2596400 - 1278 WP_256879194.1 branched chain amino acid ABC transporter permease LivM -
PS045_RS12670 (2596397) 2596397..2597323 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS045_RS12675 (2597371) 2597371..2598480 - 1110 WP_256879195.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS045_RS12680 (2598904) 2598904..2599287 + 384 WP_000778774.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS045_RS12685 (2599284) 2599284..2599811 - 528 WP_000342453.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS045_RS12690 (2599818) 2599818..2600084 - 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS045_RS12695 (2600234) 2600234..2601337 - 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS045_RS12700 (2601860) 2601860..2602261 + 402 WP_001071334.1 PTS sugar transporter subunit IIA -
PS045_RS12705 (2602268) 2602268..2602753 + 486 WP_000029259.1 PTS sugar transporter subunit IIB -
PS045_RS12710 (2602770) 2602770..2603516 + 747 WP_000151888.1 PTS sugar transporter subunit IIC -
PS045_RS12715 (2603509) 2603509..2604363 + 855 WP_000370584.1 PTS system mannose/fructose/sorbose family transporter subunit IID -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19676.58 Da        Isoelectric Point: 6.9585

>T271526 WP_000342453.1 NZ_CP117583:c2599811-2599284 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT271526 WP_001277106.1 NZ_CP117583:c2600084-2599818 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References