Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2007880..2008531 Replicon chromosome
Accession NZ_CP117583
Organism Escherichia albertii strain BIA_41

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS045_RS09760 Protein ID WP_000244763.1
Coordinates 2007880..2008284 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS045_RS09765 Protein ID WP_000354046.1
Coordinates 2008265..2008531 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS045_RS09740 (2003838) 2003838..2005571 - 1734 WP_059258720.1 single-stranded-DNA-specific exonuclease RecJ -
PS045_RS09745 (2005577) 2005577..2006287 - 711 WP_000748105.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS045_RS09750 (2006312) 2006312..2007208 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS045_RS09755 (2007320) 2007320..2007841 + 522 WP_125060507.1 flavodoxin FldB -
PS045_RS09760 (2007880) 2007880..2008284 - 405 WP_000244763.1 protein YgfX Toxin
PS045_RS09765 (2008265) 2008265..2008531 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS045_RS09770 (2008521) 2008521..2008751 - 231 WP_000181267.1 hypothetical protein -
PS045_RS09775 (2008783) 2008783..2009763 + 981 WP_256878858.1 tRNA-modifying protein YgfZ -
PS045_RS09780 (2010203) 2010203..2010862 - 660 WP_000250281.1 hemolysin III family protein -
PS045_RS09785 (2011030) 2011030..2011341 - 312 WP_001182937.1 N(4)-acetylcytidine aminohydrolase -
PS045_RS09790 (2011386) 2011386..2012819 + 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271523 WP_000244763.1 NZ_CP117583:c2008284-2007880 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271523 WP_000354046.1 NZ_CP117583:c2008531-2008265 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References