Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 31901..32544 Replicon plasmid pEA47_1
Accession NZ_CP117581
Organism Escherichia albertii strain BIA_47

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag PS044_RS22460 Protein ID WP_256876211.1
Coordinates 31901..32317 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag PS044_RS22465 Protein ID WP_256876210.1
Coordinates 32314..32544 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS044_RS22440 (PS044_22440) 27876..28253 + 378 WP_273808774.1 hypothetical protein -
PS044_RS22450 (PS044_22450) 29416..30573 + 1158 WP_256880773.1 AAA family ATPase -
PS044_RS22455 (PS044_22455) 30781..31761 - 981 WP_256876212.1 hypothetical protein -
PS044_RS22460 (PS044_22460) 31901..32317 - 417 WP_256876211.1 type II toxin-antitoxin system VapC family toxin Toxin
PS044_RS22465 (PS044_22465) 32314..32544 - 231 WP_256876210.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PS044_RS22470 (PS044_22470) 33114..33464 + 351 WP_256880772.1 hypothetical protein -
PS044_RS22475 (PS044_22475) 33504..34214 + 711 WP_256880771.1 hypothetical protein -
PS044_RS22480 (PS044_22480) 34227..35009 + 783 WP_256880770.1 site-specific integrase -
PS044_RS22485 (PS044_22485) 35148..35423 - 276 WP_256880769.1 CopG family transcriptional regulator -
PS044_RS22490 (PS044_22490) 35417..36061 - 645 WP_256880768.1 AAA family ATPase -
PS044_RS22495 (PS044_22495) 36290..37261 + 972 WP_256880767.1 plasmid segregation protein ParM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - espL2 1..40979 40979


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.41 Da        Isoelectric Point: 6.7125

>T271513 WP_256876211.1 NZ_CP117581:c32317-31901 [Escherichia albertii]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAISGHAIAAGAILVTNNTREFERVPGLILEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8678.80 Da        Isoelectric Point: 4.6017

>AT271513 WP_256876210.1 NZ_CP117581:c32544-32314 [Escherichia albertii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGGSIILRPVRPTWGSFAQLEKADPDFMAEREDVISDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References