Detailed information of TA system TA271512

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4230079..4231123
• Replicon: chromosome
• Accession: NZ_CP117580
• Organism: Escherichia albertii strain BIA_47

Toxin (Protein)

• Gene name: panT
• Uniprot ID: A0A8I0CFN6
• Locus tag: PS044_RS20595
• Protein ID: WP_059274466.1
• Coordinates: 4230079..4230627 (-)
• Length: 183 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A839B6W4
• Locus tag: PS044_RS20600
• Protein ID: WP_000287252.1
• Coordinates: 4230650..4231123 (-)
• Length: 158 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PS044_RS20540 (4225113)	4225113..4225253	-	141	Protein_4015	replication protein P	-
PS044_RS20545 (4225250)	4225250..4225468	+	219	Protein_4016	DNA recombinase	-
PS044_RS20550 (4225452)	4225452..4225934	+	483	WP_059216138.1	siphovirus Gp157 family protein	-
PS044_RS20555 (4225946)	4225946..4226260	+	315	WP_059216137.1	hypothetical protein	-
PS044_RS20560 (4226277)	4226277..4226441	+	165	Protein_4019	DUF2737 family protein	-
PS044_RS20565 (4226438)	4226438..4226998	+	561	WP_059238939.1	hypothetical protein	-
PS044_RS20570 (4227215)	4227215..4227874	+	660	WP_059238951.1	ead/Ea22-like family protein	-
PS044_RS20575 (4227876)	4227876..4228054	+	179	Protein_4022	hypothetical protein	-
PS044_RS20580 (4228388)	4228388..4229167	+	780	WP_256876784.1	DUF551 domain-containing protein	-
PS044_RS20585 (4229167)	4229167..4229739	+	573	WP_001061339.1	3'-5' exonuclease	-
PS044_RS20590 (4229776)	4229776..4230045	+	270	WP_001093912.1	pyocin activator PrtN family protein	-
PS044_RS20595 (4230079)	4230079..4230627	-	549	WP_059274466.1	hypothetical protein	Toxin
PS044_RS20600 (4230650)	4230650..4231123	-	474	WP_000287252.1	DUF4065 domain-containing protein	Antitoxin
PS044_RS20605 (4231646)	4231646..4232161	+	516	WP_002460756.1	zinc uptake transcriptional repressor Zur	-
PS044_RS20610 (4232202)	4232202..4232411	-	210	WP_001030604.1	CsbD family protein	-
PS044_RS20615 (4232527)	4232527..4233852	-	1326	WP_025237884.1	MATE family efflux transporter DinF	-
PS044_RS20620 (4233927)	4233927..4234535	-	609	WP_256876786.1	transcriptional repressor LexA	-
PS044_RS20625 (4234645)	4234645..4235013	-	369	WP_000002912.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4210146..4244259	34113

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-123)

Sequences

Toxin

Protein

• Length: 183 a.a.
• Molecular weight: 20052.43 Da
• Isoelectric Point: 4.4481

>T271512 WP_059274466.1 NZ_CP117580:c4230627-4230079 [Escherichia albertii]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Nucleotide

• Length: 549 bp

Antitoxin

Protein

• Length: 158 a.a.
• Molecular weight: 17298.80 Da
• Isoelectric Point: 8.4143

>AT271512 WP_000287252.1 NZ_CP117580:c4231123-4230650 [Escherichia albertii]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Nucleotide

• Length: 474 bp

Structures

Antitoxin

• AlphaFold DB: A0A839B6W4