Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3319801..3320419 Replicon chromosome
Accession NZ_CP117580
Organism Escherichia albertii strain BIA_47

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS044_RS16210 Protein ID WP_001280991.1
Coordinates 3320201..3320419 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS044_RS16205 Protein ID WP_000344798.1
Coordinates 3319801..3320175 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS044_RS16195 (3314881) 3314881..3316074 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS044_RS16200 (3316097) 3316097..3319246 + 3150 WP_273807810.1 efflux RND transporter permease AcrB -
PS044_RS16205 (3319801) 3319801..3320175 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS044_RS16210 (3320201) 3320201..3320419 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS044_RS16215 (3320596) 3320596..3321153 + 558 WP_025237467.1 maltose O-acetyltransferase -
PS044_RS16220 (3321260) 3321260..3321730 + 471 WP_000136188.1 YlaC family protein -
PS044_RS16225 (3321894) 3321894..3323444 + 1551 WP_001260378.1 EAL domain-containing protein -
PS044_RS16230 (3323482) 3323482..3323835 - 354 WP_000878151.1 DUF1428 family protein -
PS044_RS16240 (3324216) 3324216..3324527 + 312 WP_000409915.1 MGMT family protein -
PS044_RS16245 (3324557) 3324557..3325129 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271506 WP_001280991.1 NZ_CP117580:3320201-3320419 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271506 WP_000344798.1 NZ_CP117580:3319801-3320175 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References