Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2321998..2322602 Replicon chromosome
Accession NZ_CP117580
Organism Escherichia albertii strain BIA_47

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag PS044_RS11330 Protein ID WP_000638401.1
Coordinates 2322216..2322602 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS044_RS11325 Protein ID WP_001195490.1
Coordinates 2321998..2322219 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS044_RS11310 (2318248) 2318248..2319699 + 1452 WP_000854601.1 tagaturonate reductase -
PS044_RS11315 (2319904) 2319904..2320818 + 915 WP_024164792.1 bestrophin family protein -
PS044_RS11320 (2320822) 2320822..2321580 - 759 WP_025239009.1 trans-aconitate 2-methyltransferase -
PS044_RS11325 (2321998) 2321998..2322219 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS044_RS11330 (2322216) 2322216..2322602 + 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS044_RS11335 (2322682) 2322682..2323194 - 513 Protein_2217 autotransporter outer membrane beta-barrel domain-containing protein -
PS044_RS11340 (2323748) 2323748..2324976 + 1229 WP_273807532.1 IS3 family transposase -
PS044_RS11345 (2324987) 2324987..2326453 + 1467 WP_256876879.1 sulfatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T271504 WP_000638401.1 NZ_CP117580:2322216-2322602 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271504 WP_001195490.1 NZ_CP117580:2321998-2322219 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References