Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 766008..766659 Replicon chromosome
Accession NZ_CP117580
Organism Escherichia albertii strain BIA_47

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS044_RS03725 Protein ID WP_000244763.1
Coordinates 766008..766412 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS044_RS03730 Protein ID WP_000354046.1
Coordinates 766393..766659 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS044_RS03705 (761966) 761966..763699 - 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -
PS044_RS03710 (763705) 763705..764415 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS044_RS03715 (764440) 764440..765336 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS044_RS03720 (765448) 765448..765969 + 522 WP_025238422.1 flavodoxin FldB -
PS044_RS03725 (766008) 766008..766412 - 405 WP_000244763.1 protein YgfX Toxin
PS044_RS03730 (766393) 766393..766659 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS044_RS03735 (766649) 766649..766879 - 231 WP_000181267.1 hypothetical protein -
PS044_RS03740 (766911) 766911..767891 + 981 WP_025238421.1 tRNA-modifying protein YgfZ -
PS044_RS03745 (768331) 768331..768990 - 660 WP_000250281.1 hemolysin III family protein -
PS044_RS03750 (769158) 769158..769469 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS044_RS03755 (769514) 769514..770947 + 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271497 WP_000244763.1 NZ_CP117580:c766412-766008 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271497 WP_000354046.1 NZ_CP117580:c766659-766393 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References