Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 162841..163453 Replicon chromosome
Accession NZ_CP117580
Organism Escherichia albertii strain BIA_47

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag PS044_RS00740 Protein ID WP_000833473.1
Coordinates 162841..163026 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag PS044_RS00745 Protein ID WP_000499744.1
Coordinates 163043..163453 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS044_RS00725 (158305) 158305..159600 + 1296 WP_025238096.1 Fic family protein -
PS044_RS00730 (159708) 159708..161246 + 1539 WP_010327692.1 aldehyde dehydrogenase AldB -
PS044_RS00735 (161287) 161287..162366 - 1080 WP_025238097.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
PS044_RS00740 (162841) 162841..163026 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
PS044_RS00745 (163043) 163043..163453 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PS044_RS00750 (163525) 163525..165489 - 1965 Protein_148 glycoside hydrolase family 127 protein -
PS044_RS00755 (165500) 165500..166900 - 1401 WP_025238099.1 MFS transporter -
PS044_RS00760 (167126) 167126..167941 + 816 WP_025238100.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T271494 WP_000833473.1 NZ_CP117580:162841-163026 [Escherichia albertii]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT271494 WP_000499744.1 NZ_CP117580:163043-163453 [Escherichia albertii]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References