Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 89406..90163 Replicon plasmid pEA5_1
Accession NZ_CP117576
Organism Escherichia albertii strain BIA_5

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag PS037_RS23560 Protein ID WP_273821915.1
Coordinates 89406..89891 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag PS037_RS23565 Protein ID WP_273821916.1
Coordinates 89879..90163 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS037_RS23525 (84596) 84596..85012 - 417 WP_001278817.1 plasmid partitioning/stability family protein -
PS037_RS23530 (85005) 85005..85985 - 981 WP_000688514.1 plasmid segregation protein ParM -
PS037_RS23535 (86399) 86399..86704 - 306 WP_273821913.1 molecular chaperone GroEL -
PS037_RS23540 (86791) 86791..87435 - 645 WP_273821914.1 ParA family protein -
PS037_RS23545 (87615) 87615..88411 - 797 Protein_87 site-specific integrase -
PS037_RS23550 (88412) 88412..88715 - 304 Protein_88 type II toxin-antitoxin system toxin CcdB -
PS037_RS23555 (88717) 88717..88935 - 219 WP_000813638.1 type II toxin-antitoxin system antitoxin CcdA -
PS037_RS23560 (89406) 89406..89891 - 486 WP_273821915.1 GNAT family N-acetyltransferase Toxin
PS037_RS23565 (89879) 89879..90163 - 285 WP_273821916.1 DUF1778 domain-containing protein Antitoxin
PS037_RS23570 (90915) 90915..92126 + 1212 WP_273821917.1 YadA-like family protein -
PS037_RS23575 (92253) 92253..93452 - 1200 WP_273821918.1 lipoprotein-releasing ABC transporter permease subunit LolC -
PS037_RS23580 (93916) 93916..94118 - 203 Protein_94 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hsiC1/vipB / hsiB1/vipA / faeJ / faeI / faeH / faeF / faeE / faeD / faeC 1..143188 143188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-149)

Antitoxin

Vibrio phage ICP1, Orf50

(12-88)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17680.53 Da        Isoelectric Point: 9.9107

>T271493 WP_273821915.1 NZ_CP117576:c89891-89406 [Escherichia albertii]
MGCVTAPEPLSSFHQAAEFVSGEVVLDDWLKQKGLKNQVLGATRTFVVCRKGTQQIVGFYSLVTGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSFRGKGLGADLLHDAVRRCYRVAENIGVRAIMVHALTESAKQFYIHHGLTPSKTQVQTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10915.62 Da        Isoelectric Point: 4.6926

>AT271493 WP_273821916.1 NZ_CP117576:c90163-89879 [Escherichia albertii]
MIYGGFMKSGVQLNLRARESQRILIDTAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDKQYEEFIEMLDAPVADEP
AIEKLLVRKPQWDV

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References