Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 63867..64492 Replicon plasmid pEA5_1
Accession NZ_CP117576
Organism Escherichia albertii strain BIA_5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PS037_RS23400 Protein ID WP_273821952.1
Coordinates 64094..64492 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PS037_RS23395 Protein ID WP_039520356.1
Coordinates 63867..64094 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS037_RS23395 (63867) 63867..64094 + 228 WP_039520356.1 toxin-antitoxin system antitoxin VapB Antitoxin
PS037_RS23400 (64094) 64094..64492 + 399 WP_273821952.1 type II toxin-antitoxin system VapC family toxin Toxin
PS037_RS23405 (64501) 64501..65130 - 630 Protein_59 type IV secretion system DNA-binding domain-containing protein -
PS037_RS23410 (65195) 65195..65977 - 783 WP_001317493.1 IS21-like element IS100kyp family helper ATPase IstB -
PS037_RS23415 (65974) 65974..66996 - 1023 WP_273821257.1 IS21-like element IS100 family transposase -
PS037_RS23420 (67053) 67053..67304 + 252 WP_273821953.1 hypothetical protein -
PS037_RS23425 (67820) 67820..68269 - 450 WP_273821954.1 CaiF/GrlA family transcriptional regulator -
PS037_RS23430 (68585) 68585..69358 - 774 WP_273821955.1 F4 (K88) fimbria accessory protein FaeJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hsiC1/vipB / hsiB1/vipA / faeJ / faeI / faeH / faeF / faeE / faeD / faeC 1..143188 143188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-40)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14945.21 Da        Isoelectric Point: 7.8605

>T271492 WP_273821952.1 NZ_CP117576:64094-64492 [Escherichia albertii]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDATAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 4.4013

>AT271492 WP_039520356.1 NZ_CP117576:63867-64094 [Escherichia albertii]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRARIITPAGETWDEWFDGNSVSADFMDNREQSDMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References