Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 53282..53829 Replicon plasmid pEA5_1
Accession NZ_CP117576
Organism Escherichia albertii strain BIA_5

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PS037_RS23350 Protein ID WP_244427497.1
Coordinates 53282..53560 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag PS037_RS23355 Protein ID WP_069917659.1
Coordinates 53560..53829 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS037_RS23330 (48474) 48474..48968 - 495 WP_262253771.1 SH3 domain-containing protein -
PS037_RS23340 (51489) 51489..51827 + 339 WP_069917657.1 transposase -
PS037_RS23345 (51827) 51827..53014 + 1188 WP_089552989.1 IS91 family transposase -
PS037_RS23350 (53282) 53282..53560 - 279 WP_244427497.1 type II toxin-antitoxin system toxin YacB Toxin
PS037_RS23355 (53560) 53560..53829 - 270 WP_069917659.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PS037_RS23360 (54751) 54751..55608 - 858 WP_021559031.1 incFII family plasmid replication initiator RepA -
PS037_RS23365 (55601) 55601..55675 - 75 WP_001365705.1 RepA leader peptide Tap -
PS037_RS23370 (55921) 55921..56169 - 249 WP_273821949.1 replication regulatory protein RepA -
PS037_RS23375 (56794) 56794..56994 - 201 WP_273821950.1 hypothetical protein -
PS037_RS23380 (57134) 57134..57694 - 561 WP_072661996.1 fertility inhibition protein FinO -
PS037_RS23385 (57749) 57749..58495 - 747 WP_273821951.1 conjugal transfer pilus acetylase TraX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hsiC1/vipB / hsiB1/vipA / faeJ / faeI / faeH / faeF / faeE / faeD / faeC 1..143188 143188
- flank IS/Tn - - 51827..53014 1187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10743.33 Da        Isoelectric Point: 7.3987

>T271491 WP_244427497.1 NZ_CP117576:c53560-53282 [Escherichia albertii]
MEIFWTMLASQDRKHIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10263.59 Da        Isoelectric Point: 8.8736

>AT271491 WP_069917659.1 NZ_CP117576:c53829-53560 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDIVESSATAWRN
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References