Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4311387..4312005 Replicon chromosome
Accession NZ_CP117575
Organism Escherichia albertii strain BIA_5

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS037_RS20750 Protein ID WP_001280991.1
Coordinates 4311387..4311605 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag PS037_RS20755 Protein ID WP_273821340.1
Coordinates 4311631..4312005 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS037_RS20715 (4306677) 4306677..4307249 + 573 WP_059256696.1 YbaY family lipoprotein -
PS037_RS20720 (4307279) 4307279..4307590 - 312 WP_000409915.1 MGMT family protein -
PS037_RS20730 (4307971) 4307971..4308324 + 354 WP_000878150.1 DUF1428 family protein -
PS037_RS20735 (4308362) 4308362..4309912 - 1551 WP_273821339.1 EAL domain-containing protein -
PS037_RS20740 (4310076) 4310076..4310546 - 471 WP_059224581.1 YlaC family protein -
PS037_RS20745 (4310653) 4310653..4311210 - 558 WP_025237467.1 maltose O-acetyltransferase -
PS037_RS20750 (4311387) 4311387..4311605 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS037_RS20755 (4311631) 4311631..4312005 - 375 WP_273821340.1 Hha toxicity modulator TomB Antitoxin
PS037_RS20760 (4312560) 4312560..4315709 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS037_RS20765 (4315732) 4315732..4316925 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271490 WP_001280991.1 NZ_CP117575:c4311605-4311387 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.41 Da        Isoelectric Point: 4.8989

>AT271490 WP_273821340.1 NZ_CP117575:c4312005-4311631 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNVTKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References