Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3182595..3183211 Replicon chromosome
Accession NZ_CP117575
Organism Escherichia albertii strain BIA_5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PS037_RS15420 Protein ID WP_107192776.1
Coordinates 3182837..3183211 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PS037_RS15415 Protein ID WP_103054107.1
Coordinates 3182595..3182837 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS037_RS15375 (3177887) 3177887..3178324 + 438 WP_000560979.1 D-aminoacyl-tRNA deacylase -
PS037_RS15380 (3178369) 3178369..3179310 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
PS037_RS15385 (3179374) 3179374..3180282 - 909 WP_059239594.1 alpha/beta hydrolase -
PS037_RS15390 (3180511) 3180511..3180822 + 312 WP_000897302.1 hypothetical protein -
PS037_RS15395 (3180823) 3180823..3181113 + 291 WP_000356397.1 NadS family protein -
PS037_RS15400 (3181198) 3181198..3181410 + 213 WP_000197774.1 hypothetical protein -
PS037_RS15405 (3181472) 3181472..3181750 + 279 WP_032278934.1 hypothetical protein -
PS037_RS15410 (3182149) 3182149..3182367 + 219 WP_001314326.1 CopG family transcriptional regulator -
PS037_RS15415 (3182595) 3182595..3182837 + 243 WP_103054107.1 CopG family transcriptional regulator Antitoxin
PS037_RS15420 (3182837) 3182837..3183211 + 375 WP_107192776.1 type II toxin-antitoxin system VapC family toxin Toxin
PS037_RS15425 (3183248) 3183248..3184177 - 930 WP_000027704.1 formate dehydrogenase accessory protein FdhE -
PS037_RS15430 (3184174) 3184174..3184809 - 636 WP_000829019.1 formate dehydrogenase cytochrome b556 subunit -
PS037_RS15435 (3184806) 3184806..3185708 - 903 WP_000331386.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-48)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13944.15 Da        Isoelectric Point: 8.4539

>T271486 WP_107192776.1 NZ_CP117575:3182837-3183211 [Escherichia albertii]
MAKRTALFDTNILIDLFSGRIESKQALEAWPLQNAISLVTWMEVLVGAKKYNQEHRTQIAMSAFNVIGISQDIAERSVAL
RQEYRMKLPDAIILATAQIYGFELVTRNTRDFAGIAGVITPYQP

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9272.61 Da        Isoelectric Point: 4.4819

>AT271486 WP_103054107.1 NZ_CP117575:3182595-3182837 [Escherichia albertii]
MSAMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVAQYLENQSKTTIFSALGIWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References