Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2049871..2050522 Replicon chromosome
Accession NZ_CP117575
Organism Escherichia albertii strain BIA_5

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS037_RS09915 Protein ID WP_000244763.1
Coordinates 2049871..2050275 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS037_RS09920 Protein ID WP_000354046.1
Coordinates 2050256..2050522 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS037_RS09895 (2045834) 2045834..2047567 - 1734 WP_273821829.1 single-stranded-DNA-specific exonuclease RecJ -
PS037_RS09900 (2047573) 2047573..2048283 - 711 WP_273821830.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS037_RS09905 (2048308) 2048308..2049204 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS037_RS09910 (2049316) 2049316..2049837 + 522 WP_273821831.1 flavodoxin FldB -
PS037_RS09915 (2049871) 2049871..2050275 - 405 WP_000244763.1 protein YgfX Toxin
PS037_RS09920 (2050256) 2050256..2050522 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS037_RS09925 (2050512) 2050512..2050742 - 231 WP_000181267.1 hypothetical protein -
PS037_RS09930 (2050774) 2050774..2051754 + 981 WP_059273222.1 tRNA-modifying protein YgfZ -
PS037_RS09935 (2051956) 2051956..2052615 - 660 WP_000250281.1 hemolysin III family protein -
PS037_RS09940 (2052783) 2052783..2053094 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS037_RS09945 (2053139) 2053139..2054572 + 1434 WP_024164724.1 6-phospho-beta-glucosidase BglA -
PS037_RS09950 (2054620) 2054620..2055513 - 894 WP_059214571.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271479 WP_000244763.1 NZ_CP117575:c2050275-2049871 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271479 WP_000354046.1 NZ_CP117575:c2050522-2050256 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References