Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 63191..63816 Replicon plasmid pEA50_1
Accession NZ_CP117571
Organism Escherichia albertii strain BIA_50

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PS035_RS23120 Protein ID WP_000911313.1
Coordinates 63418..63816 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag PS035_RS23115 Protein ID WP_000450520.1
Coordinates 63191..63418 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS035_RS23115 (63191) 63191..63418 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
PS035_RS23120 (63418) 63418..63816 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
PS035_RS23125 (63825) 63825..66023 - 2199 WP_273818024.1 type IV conjugative transfer system coupling protein TraD -
PS035_RS23130 (66276) 66276..67007 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
PS035_RS23135 (67039) 67039..67536 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD vat / iutA / iucD / iucC / iucB / iucA / espK / paa / vat 1..165614 165614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T271465 WP_000911313.1 NZ_CP117571:63418-63816 [Escherichia albertii]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT271465 WP_000450520.1 NZ_CP117571:63191-63418 [Escherichia albertii]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References