Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3412633..3413251 Replicon chromosome
Accession NZ_CP117570
Organism Escherichia albertii strain BIA_50

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS035_RS16535 Protein ID WP_001280991.1
Coordinates 3413033..3413251 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS035_RS16530 Protein ID WP_000344798.1
Coordinates 3412633..3413007 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS035_RS16520 (3407713) 3407713..3408906 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS035_RS16525 (3408929) 3408929..3412078 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS035_RS16530 (3412633) 3412633..3413007 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS035_RS16535 (3413033) 3413033..3413251 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS035_RS16540 (3413428) 3413428..3413985 + 558 WP_273817357.1 maltose O-acetyltransferase -
PS035_RS16545 (3414093) 3414093..3414563 + 471 WP_000136187.1 YlaC family protein -
PS035_RS16550 (3414727) 3414727..3416277 + 1551 WP_273817358.1 EAL domain-containing protein -
PS035_RS16555 (3416315) 3416315..3416668 - 354 WP_000878151.1 DUF1428 family protein -
PS035_RS16565 (3417049) 3417049..3417360 + 312 WP_000409915.1 MGMT family protein -
PS035_RS16570 (3417390) 3417390..3417962 - 573 WP_273817359.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271457 WP_001280991.1 NZ_CP117570:3413033-3413251 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271457 WP_000344798.1 NZ_CP117570:3412633-3413007 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References