Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2323964..2324568 Replicon chromosome
Accession NZ_CP117570
Organism Escherichia albertii strain BIA_50

Toxin (Protein)


Gene name doc Uniprot ID B1EM00
Locus tag PS035_RS11220 Protein ID WP_000638401.1
Coordinates 2324182..2324568 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS035_RS11215 Protein ID WP_001195490.1
Coordinates 2323964..2324185 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS035_RS11200 (2320214) 2320214..2321665 + 1452 WP_273786478.1 tagaturonate reductase -
PS035_RS11205 (2321870) 2321870..2322784 + 915 WP_024164792.1 bestrophin family protein -
PS035_RS11210 (2322788) 2322788..2323546 - 759 WP_044709411.1 trans-aconitate 2-methyltransferase -
PS035_RS11215 (2323964) 2323964..2324185 + 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS035_RS11220 (2324182) 2324182..2324568 + 387 WP_000638401.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS035_RS11225 (2324648) 2324648..2326069 - 1422 WP_273817964.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14505.49 Da        Isoelectric Point: 8.0833

>T271455 WP_000638401.1 NZ_CP117570:2324182-2324568 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MTFLWRNGIRIRDVDNSLENLTVEAATGEKTVGQLARCLRERVDSSGN

Download         Length: 387 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271455 WP_001195490.1 NZ_CP117570:2323964-2324185 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T5VDW2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References