Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4193761..4194379 Replicon chromosome
Accession NZ_CP117568
Organism Escherichia albertii strain BIA_5-2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS053_RS20225 Protein ID WP_001280991.1
Coordinates 4193761..4193979 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS053_RS20230 Protein ID WP_000344798.1
Coordinates 4194005..4194379 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS053_RS20190 (4189051) 4189051..4189623 + 573 WP_000779847.1 YbaY family lipoprotein -
PS053_RS20195 (4189653) 4189653..4189964 - 312 WP_000409915.1 MGMT family protein -
PS053_RS20205 (4190345) 4190345..4190698 + 354 WP_000878151.1 DUF1428 family protein -
PS053_RS20210 (4190736) 4190736..4192286 - 1551 WP_001260378.1 EAL domain-containing protein -
PS053_RS20215 (4192450) 4192450..4192920 - 471 WP_059224581.1 YlaC family protein -
PS053_RS20220 (4193027) 4193027..4193584 - 558 WP_025237467.1 maltose O-acetyltransferase -
PS053_RS20225 (4193761) 4193761..4193979 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS053_RS20230 (4194005) 4194005..4194379 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS053_RS20235 (4194934) 4194934..4198083 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS053_RS20240 (4198106) 4198106..4199299 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271445 WP_001280991.1 NZ_CP117568:c4193979-4193761 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271445 WP_000344798.1 NZ_CP117568:c4194379-4194005 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References