Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 3616484..3617191 Replicon chromosome
Accession NZ_CP117568
Organism Escherichia albertii strain BIA_5-2

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag PS053_RS17580 Protein ID WP_130222476.1
Coordinates 3616850..3617191 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag PS053_RS17575 Protein ID WP_130222474.1
Coordinates 3616484..3616819 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS053_RS17550 (3612430) 3612430..3612649 - 220 Protein_3420 AlpA family phage regulatory protein -
PS053_RS17555 (3612767) 3612767..3613381 - 615 WP_256878726.1 inovirus Gp2 family protein -
PS053_RS17560 (3613973) 3613973..3614926 + 954 WP_256878725.1 hypothetical protein -
PS053_RS17565 (3615163) 3615163..3615981 + 819 WP_256878724.1 DUF932 domain-containing protein -
PS053_RS17570 (3616011) 3616011..3616484 + 474 WP_256878723.1 DNA repair protein RadC -
PS053_RS17575 (3616484) 3616484..3616819 + 336 WP_130222474.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PS053_RS17580 (3616850) 3616850..3617191 + 342 WP_130222476.1 TA system toxin CbtA family protein Toxin
PS053_RS17585 (3617306) 3617306..3618140 + 835 Protein_3427 DUF4942 domain-containing protein -
PS053_RS17590 (3618216) 3618216..3618464 + 249 WP_000535212.1 ribbon-helix-helix domain-containing protein -
PS053_RS17595 (3618468) 3618468..3618743 + 276 WP_001683517.1 type II toxin-antitoxin system RelE/ParE family toxin -
PS053_RS17600 (3618858) 3618858..3619655 + 798 WP_256878721.1 helix-turn-helix transcriptional regulator -
PS053_RS17605 (3619909) 3619909..3620445 + 537 WP_059221727.1 hypothetical protein -
PS053_RS17610 (3620776) 3620776..3621333 + 558 WP_256878720.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - nleB1 / nleE / vat 3609281..3631125 21844


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(10-109)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13047.09 Da        Isoelectric Point: 9.9072

>T271439 WP_130222476.1 NZ_CP117568:3616850-3617191 [Escherichia albertii]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAINFLVEKYQLIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRCHNTATR

Download         Length: 342 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12562.57 Da        Isoelectric Point: 8.1330

>AT271439 WP_130222474.1 NZ_CP117568:3616484-3616819 [Escherichia albertii]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLNYLADRAAITGKFSSPDLLHIDQAFPVLMKQRELKLADGELSPCQQR
TVTLHAKGLTCEADTLGSCGYVYIAIYPIQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References