Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2601730..2602530 Replicon chromosome
Accession NZ_CP117568
Organism Escherichia albertii strain BIA_5-2

Toxin (Protein)


Gene name ataT Uniprot ID B1EHN9
Locus tag PS053_RS12695 Protein ID WP_000342453.1
Coordinates 2601730..2602257 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS053_RS12700 Protein ID WP_001277106.1
Coordinates 2602264..2602530 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS053_RS12670 (2596805) 2596805..2597572 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PS053_RS12675 (2597569) 2597569..2598846 - 1278 WP_256879194.1 branched chain amino acid ABC transporter permease LivM -
PS053_RS12680 (2598843) 2598843..2599769 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS053_RS12685 (2599817) 2599817..2600926 - 1110 WP_256879195.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS053_RS12690 (2601350) 2601350..2601733 + 384 WP_000778774.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS053_RS12695 (2601730) 2601730..2602257 - 528 WP_000342453.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS053_RS12700 (2602264) 2602264..2602530 - 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS053_RS12705 (2602680) 2602680..2603783 - 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS053_RS12710 (2604306) 2604306..2604707 + 402 WP_001071334.1 PTS sugar transporter subunit IIA -
PS053_RS12715 (2604714) 2604714..2605199 + 486 WP_000029259.1 PTS sugar transporter subunit IIB -
PS053_RS12720 (2605216) 2605216..2605962 + 747 WP_000151888.1 PTS sugar transporter subunit IIC -
PS053_RS12725 (2605955) 2605955..2606809 + 855 WP_000370584.1 PTS system mannose/fructose/sorbose family transporter subunit IID -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19676.58 Da        Isoelectric Point: 6.9585

>T271436 WP_000342453.1 NZ_CP117568:c2602257-2601730 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT271436 WP_001277106.1 NZ_CP117568:c2602530-2602264 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References