Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2010326..2010977 Replicon chromosome
Accession NZ_CP117568
Organism Escherichia albertii strain BIA_5-2

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS053_RS09770 Protein ID WP_000244763.1
Coordinates 2010326..2010730 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS053_RS09775 Protein ID WP_000354046.1
Coordinates 2010711..2010977 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS053_RS09750 (2006284) 2006284..2008017 - 1734 WP_059258720.1 single-stranded-DNA-specific exonuclease RecJ -
PS053_RS09755 (2008023) 2008023..2008733 - 711 WP_000748105.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS053_RS09760 (2008758) 2008758..2009654 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS053_RS09765 (2009766) 2009766..2010287 + 522 WP_125060507.1 flavodoxin FldB -
PS053_RS09770 (2010326) 2010326..2010730 - 405 WP_000244763.1 protein YgfX Toxin
PS053_RS09775 (2010711) 2010711..2010977 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS053_RS09780 (2010967) 2010967..2011197 - 231 WP_000181267.1 hypothetical protein -
PS053_RS09785 (2011229) 2011229..2012209 + 981 WP_256878858.1 tRNA-modifying protein YgfZ -
PS053_RS09790 (2012649) 2012649..2013308 - 660 WP_000250281.1 hemolysin III family protein -
PS053_RS09795 (2013476) 2013476..2013787 - 312 WP_001182937.1 N(4)-acetylcytidine aminohydrolase -
PS053_RS09800 (2013832) 2013832..2015265 + 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271433 WP_000244763.1 NZ_CP117568:c2010730-2010326 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271433 WP_000354046.1 NZ_CP117568:c2010977-2010711 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References