Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 30559..31322 Replicon plasmid pEA7_2
Accession NZ_CP117564
Organism Escherichia albertii strain BIA_7

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag PS049_RS25730 Protein ID WP_000405251.1
Coordinates 30559..31041 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag PS049_RS25735 Protein ID WP_001143303.1
Coordinates 31032..31322 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS049_RS25695 (PS049_25695) 26349..26828 + 480 Protein_34 integrase core domain-containing protein -
PS049_RS25700 (PS049_25700) 26927..27505 + 579 WP_137653473.1 hypothetical protein -
PS049_RS25705 (PS049_25705) 27555..27662 - 108 Protein_36 type II toxin-antitoxin system toxin YacB -
PS049_RS25710 (PS049_25710) 27662..27916 - 255 WP_149452403.1 type II toxin-antitoxin system antitoxin YacA -
PS049_RS25715 (PS049_25715) 28833..29690 - 858 WP_137653556.1 incFII family plasmid replication initiator RepA -
PS049_RS25720 (PS049_25720) 29683..29757 - 75 WP_001375168.1 RepA leader peptide Tap -
PS049_RS25725 (PS049_25725) 29989..30249 - 261 WP_000078113.1 replication regulatory protein RepA -
PS049_RS25730 (PS049_25730) 30559..31041 - 483 WP_000405251.1 GNAT family N-acetyltransferase Toxin
PS049_RS25735 (PS049_25735) 31032..31322 - 291 WP_001143303.1 DUF1778 domain-containing protein Antitoxin
PS049_RS25740 (PS049_25740) 31622..31834 - 213 WP_001299730.1 ANR family transcriptional regulator -
PS049_RS25745 (PS049_25745) 31975..32535 - 561 WP_000139333.1 fertility inhibition protein FinO -
PS049_RS25750 (PS049_25750) 32590..33336 - 747 WP_074459549.1 conjugal transfer pilus acetylase TraX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - espL2 1..129910 129910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(33-149)

Antitoxin

Vibrio phage ICP1, Orf50

(15-90)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17672.50 Da        Isoelectric Point: 7.8646

>T271420 WP_000405251.1 NZ_CP117564:c31041-30559 [Escherichia albertii]
MEINVTAPALLTDEHILQPFDCGNKVLSNWLHGRAMKNQMLNASRTFVICLEGTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSIVAPNTLFYKV

Download         Length: 483 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11213.65 Da        Isoelectric Point: 4.7064

>AT271420 WP_001143303.1 NZ_CP117564:c31322-31032 [Escherichia albertii]
MPTTANIRKTSRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDDERYDSFITQLEAPVQ
NAEGRERLMAVKPEWK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References