Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 17458..18005 Replicon plasmid pEA7_1
Accession NZ_CP117563
Organism Escherichia albertii strain BIA_7

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PS049_RS24695 Protein ID WP_273820518.1
Coordinates 17727..18005 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag PS049_RS24690 Protein ID WP_048889353.1
Coordinates 17458..17727 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS049_RS24660 (12746) 12746..13147 - 402 WP_001541954.1 ester cyclase -
PS049_RS24665 (13156) 13156..13647 - 492 Protein_10 helix-turn-helix domain-containing protein -
PS049_RS24670 (13750) 13750..14922 + 1173 WP_053264206.1 IS21-like element IS21 family transposase -
PS049_RS24675 (14922) 14922..15719 + 798 WP_123012753.1 IS21-like element IS21 family helper ATPase IstB -
PS049_RS24680 (15779) 15779..16279 - 501 Protein_13 AraC family transcriptional regulator -
PS049_RS24685 (16295) 16295..17071 - 777 WP_064559556.1 MBL fold metallo-hydrolase -
PS049_RS24690 (17458) 17458..17727 + 270 WP_048889353.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PS049_RS24695 (17727) 17727..18005 + 279 WP_273820518.1 type II toxin-antitoxin system toxin YacB Toxin
PS049_RS24700 (18539) 18539..19390 - 852 WP_045295616.1 MBL fold metallo-hydrolase -
PS049_RS24705 (19990) 19990..21171 + 1182 WP_273820494.1 MFS transporter -
PS049_RS24710 (21410) 21410..22189 + 780 WP_273820495.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - efa1 1..177310 177310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10810.42 Da        Isoelectric Point: 8.4615

>T271414 WP_273820518.1 NZ_CP117563:17727-18005 [Escherichia albertii]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEFDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT271414 WP_048889353.1 NZ_CP117563:17458-17727 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAEGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References