Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4882170..4882788 Replicon chromosome
Accession NZ_CP117562
Organism Escherichia albertii strain BIA_7

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS049_RS24250 Protein ID WP_001280991.1
Coordinates 4882570..4882788 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS049_RS24245 Protein ID WP_000344798.1
Coordinates 4882170..4882544 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS049_RS24235 (4877250) 4877250..4878443 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS049_RS24240 (4878466) 4878466..4881615 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS049_RS24245 (4882170) 4882170..4882544 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS049_RS24250 (4882570) 4882570..4882788 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS049_RS24255 (4882965) 4882965..4883522 + 558 WP_204628716.1 maltose O-acetyltransferase -
PS049_RS24260 (4883630) 4883630..4884100 + 471 WP_000136188.1 YlaC family protein -
PS049_RS24265 (4884264) 4884264..4885814 + 1551 WP_054411428.1 EAL domain-containing protein -
PS049_RS24270 (4885852) 4885852..4886205 - 354 WP_000878151.1 DUF1428 family protein -
PS049_RS24280 (4886586) 4886586..4886897 + 312 WP_000409915.1 MGMT family protein -
PS049_RS24285 (4886927) 4886927..4887499 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271413 WP_001280991.1 NZ_CP117562:4882570-4882788 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271413 WP_000344798.1 NZ_CP117562:4882170-4882544 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References