Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2121767..2122418 Replicon chromosome
Accession NZ_CP117562
Organism Escherichia albertii strain BIA_7

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag PS049_RS10260 Protein ID WP_273820272.1
Coordinates 2122014..2122418 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS049_RS10255 Protein ID WP_000354046.1
Coordinates 2121767..2122033 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS049_RS10235 (2117477) 2117477..2118910 - 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -
PS049_RS10240 (2118955) 2118955..2119266 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PS049_RS10245 (2119434) 2119434..2120093 + 660 WP_000250281.1 hemolysin III family protein -
PS049_RS10250 (2120534) 2120534..2121514 - 981 WP_273820270.1 tRNA-modifying protein YgfZ -
PS049_RS10255 (2121767) 2121767..2122033 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS049_RS10260 (2122014) 2122014..2122418 + 405 WP_273820272.1 protein YgfX Toxin
PS049_RS10265 (2122457) 2122457..2122978 - 522 WP_273783070.1 flavodoxin FldB -
PS049_RS10270 (2123090) 2123090..2123986 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS049_RS10275 (2124011) 2124011..2124721 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS049_RS10280 (2124727) 2124727..2126460 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15918.84 Da        Isoelectric Point: 11.1732

>T271402 WP_273820272.1 NZ_CP117562:2122014-2122418 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVTAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271402 WP_000354046.1 NZ_CP117562:2121767-2122033 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References