Detailed information of TA system TA271394

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 684789..686487
• Replicon: chromosome
• Accession: NZ_CP117562
• Organism: Escherichia albertii strain BIA_7

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: PS049_RS03360
• Protein ID: WP_273782486.1
• Coordinates: 685558..686487 (+)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: PS049_RS03355
• Protein ID: WP_024165421.1
• Coordinates: 684789..685571 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PS049_RS03325 (679819)	679819..680370	+	552	WP_273782482.1	hypothetical protein	-
PS049_RS03330 (680373)	680373..680861	+	489	WP_273782483.1	DUF6521 family protein	-
PS049_RS03335 (680858)	680858..681397	+	540	WP_273820090.1	hypothetical protein	-
PS049_RS03340 (681413)	681413..682849	+	1437	WP_273782485.1	DUF3732 domain-containing protein	-
PS049_RS03345 (682930)	682930..683730	-	801	WP_000356512.1	hypothetical protein	-
PS049_RS03350 (683771)	683771..684640	-	870	WP_000547574.1	hypothetical protein	-
PS049_RS03355 (684789)	684789..685571	+	783	WP_024165421.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
PS049_RS03360 (685558)	685558..686487	+	930	WP_273782486.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PS049_RS03365 (687655)	687655..687933	-	279	WP_032279169.1	hypothetical protein	-
PS049_RS03370 (687991)	687991..689343	-	1353	WP_273820091.1	EspK/GogB family type III secretion system effector	-
PS049_RS03375 (689635)	689635..690273	-	639	WP_059258007.1	DUF1076 domain-containing protein	-
PS049_RS03380 (690471)	690471..691055	+	585	WP_273820093.1	bfpT-regulated chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	espK / espF / escG / escF / cesD2 / espB / espD / espA / sepL / escD / eae / cesT / tir / map / cesF / espH / sepQ/escQ / escO / escN / escV / cesL / sepZ/espZ / escI / escJ / sepD / escC / cesD / etgA / escU / escT / escS / escR / escL / escK / cesAB / escE / espG	678445..727515	49070

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (12-261)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (96-247)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35114.60 Da
• Isoelectric Point: 6.4965

>T271394 WP_273782486.1 NZ_CP117562:685558-686487 [Escherichia albertii]
MDLRDSYARQVRLLMTVLPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADREADLAAINDALMRITESLNGR
AGITAIRQENKTDEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEMEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLVGHPRPIAELLAPNWDTPRIATLYAQEFSGMTQRETSLESLLSVTMLLPQAL
KSHLTDRDRQFLLSYKQNTPNWSLYRYPEIQHLPAIRWKLRNLAVLNDKNPAKFAAAVSKLEGVLEQYF

Nucleotide

• Length: 930 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29286.64 Da
• Isoelectric Point: 8.4386

>AT271394 WP_024165421.1 NZ_CP117562:684789-685571 [Escherichia albertii]
MPNYLNWLMQNTLPGQVLLQSWLVRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGRQQVWLALAAYVKLPGWFVTFEQSVTFVTLYTSGLTVDVIPFTTKLNIGDRQLVGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVMLYLARRNEHPYFQYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRAFKPGGVEDGSA

Nucleotide

• Length: 783 bp