Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 1380160..1380643 | Replicon | chromosome |
Accession | NC_017622 | ||
Organism | Streptococcus suis A7 |
Toxin (Protein)
Gene name | relE | Uniprot ID | D5AIX4 |
Locus tag | SSUA7_RS06750 | Protein ID | WP_012027435.1 |
Coordinates | 1380160..1380420 (-) | Length | 87 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0Z8BIX7 |
Locus tag | SSUA7_RS06755 | Protein ID | WP_012775256.1 |
Coordinates | 1380422..1380643 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SSUA7_RS06725 | 1375545..1376774 | - | 1230 | WP_012775253.1 | tetratricopeptide repeat protein | - |
SSUA7_RS06730 | 1376764..1377930 | - | 1167 | WP_012775254.1 | AI-2E family transporter | - |
SSUA7_RS06735 | 1378066..1379070 | + | 1005 | WP_012028380.1 | lactonase family protein | - |
SSUA7_RS06740 | 1379134..1379319 | + | 186 | WP_002935693.1 | hypothetical protein | - |
SSUA7_RS06745 | 1379352..1379993 | - | 642 | WP_012775255.1 | HAD family hydrolase | - |
SSUA7_RS06750 | 1380160..1380420 | - | 261 | WP_012027435.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
SSUA7_RS06755 | 1380422..1380643 | - | 222 | WP_012775256.1 | hypothetical protein | Antitoxin |
SSUA7_RS06760 | 1380953..1382260 | - | 1308 | WP_002935704.1 | phosphopyruvate hydratase | - |
SSUA7_RS06765 | 1382410..1382862 | + | 453 | WP_012028381.1 | DUF1694 domain-containing protein | - |
SSUA7_RS10290 | 1382869..1383098 | - | 230 | Protein_1280 | hypothetical protein | - |
SSUA7_RS06770 | 1383089..1384216 | - | 1128 | WP_012028382.1 | glycerate kinase | - |
SSUA7_RS06775 | 1384324..1384974 | + | 651 | WP_012027441.1 | HAD family hydrolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | pavA | 1357319..1421934 | 64615 | |
- | flank | IS/Tn | - | - | 1385411..1386613 | 1202 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10273.79 Da Isoelectric Point: 9.3944
>T27139 WP_012027435.1 NC_017622:c1380420-1380160 [Streptococcus suis A7]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY
Download Length: 261 bp
>T27139 NC_017622:c1380420-1380160 [Streptococcus suis A7]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8566.55 Da Isoelectric Point: 4.4791
>AT27139 WP_012775256.1 NC_017622:c1380643-1380422 [Streptococcus suis A7]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL
Download Length: 222 bp
>AT27139 NC_017622:c1380643-1380422 [Streptococcus suis A7]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2K1T1M7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z8BIX7 |