Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1380160..1380643 Replicon chromosome
Accession NC_017622
Organism Streptococcus suis A7

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag SSUA7_RS06750 Protein ID WP_012027435.1
Coordinates 1380160..1380420 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSUA7_RS06755 Protein ID WP_012775256.1
Coordinates 1380422..1380643 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUA7_RS06725 1375545..1376774 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
SSUA7_RS06730 1376764..1377930 - 1167 WP_012775254.1 AI-2E family transporter -
SSUA7_RS06735 1378066..1379070 + 1005 WP_012028380.1 lactonase family protein -
SSUA7_RS06740 1379134..1379319 + 186 WP_002935693.1 hypothetical protein -
SSUA7_RS06745 1379352..1379993 - 642 WP_012775255.1 HAD family hydrolase -
SSUA7_RS06750 1380160..1380420 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUA7_RS06755 1380422..1380643 - 222 WP_012775256.1 hypothetical protein Antitoxin
SSUA7_RS06760 1380953..1382260 - 1308 WP_002935704.1 phosphopyruvate hydratase -
SSUA7_RS06765 1382410..1382862 + 453 WP_012028381.1 DUF1694 domain-containing protein -
SSUA7_RS10290 1382869..1383098 - 230 Protein_1280 hypothetical protein -
SSUA7_RS06770 1383089..1384216 - 1128 WP_012028382.1 glycerate kinase -
SSUA7_RS06775 1384324..1384974 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - pavA 1357319..1421934 64615
- flank IS/Tn - - 1385411..1386613 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T27139 WP_012027435.1 NC_017622:c1380420-1380160 [Streptococcus suis A7]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T27139 NC_017622:c1380420-1380160 [Streptococcus suis A7]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT27139 WP_012775256.1 NC_017622:c1380643-1380422 [Streptococcus suis A7]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT27139 NC_017622:c1380643-1380422 [Streptococcus suis A7]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References