Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3496910..3497528 Replicon chromosome
Accession NZ_CP117558
Organism Escherichia albertii strain BIA_8

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS052_RS17415 Protein ID WP_001280991.1
Coordinates 3497310..3497528 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS052_RS17410 Protein ID WP_000344798.1
Coordinates 3496910..3497284 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS052_RS17400 (3491990) 3491990..3493183 + 1194 WP_273764923.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PS052_RS17405 (3493206) 3493206..3496355 + 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS052_RS17410 (3496910) 3496910..3497284 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS052_RS17415 (3497310) 3497310..3497528 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PS052_RS17420 (3497705) 3497705..3498262 + 558 WP_000093561.1 maltose O-acetyltransferase -
PS052_RS17425 (3498370) 3498370..3498840 + 471 WP_273764927.1 YlaC family protein -
PS052_RS17430 (3499004) 3499004..3500554 + 1551 WP_001260378.1 EAL domain-containing protein -
PS052_RS17435 (3500592) 3500592..3500945 - 354 WP_273764929.1 DUF1428 family protein -
PS052_RS17445 (3501326) 3501326..3501637 + 312 WP_000409915.1 MGMT family protein -
PS052_RS17450 (3501667) 3501667..3502239 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271375 WP_001280991.1 NZ_CP117558:3497310-3497528 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271375 WP_000344798.1 NZ_CP117558:3496910-3497284 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References